Acetohexamide

Drug Approvals

(British Approved Name, US Adopted Name, rINN)

Synonyms: Acetohexamid; Acetohexamida; Acetohexamidum; Asetoheksamidi; Compound 33006
USAN: Acetohexamide
INN: Acetohexamide [rINN (en)]
INN: Acetohexamida [rINN (es)]
INN: Acétohexamide [rINN (fr)]
INN: Acetohexamidum [rINN (la)]
INN: Ацетогексамид [rINN (ru)]
Chemical name: 1-(4-Acetylbenzenesulphonyl)-3-cyclohexylurea
Molecular formula: C15H20N2O4S =324.4
CAS: 968-81-0
ATC code: A10BB31
Read code: y00RU

Pharmacopoeias. InJapan and US.

The United States Pharmacopeia 31, 2008 (Acetohexamide). A white, practically odourless, crystalline powder. Practically insoluble in water and in ether soluble 1 in 230 of alcohol and 1 in 210 of chloroform soluble in py-ridine and in dilute solutions of alkali hydroxides.

Profile

Acetohexamide is a sulfonylurea antidiabetic. Its duration of action is 12 hours or more. It has been given orally in the treatment of type 2 diabetes mellitus in a usual initial dose of 250 mg daily before breakfast. The daily dose may then be increased by 250 to 500 mg at intervals of 5 to 7 days, to a maintenance dose of up to 1.5 g daily increasing the dose above 1.5 g does not usually lead to further benefit. Doses in excess of 1 g daily may be taken in 2 divided doses, before the morning and evening meals.

Preparations

The United States Pharmacopeia 31, 2008: Acetohexamide Tablets.

Proprietary Preparations

Canada: Dimelor;

Hong Kong: Dimelor;

Italy: Dimelor;

South Africa: Dimelor;

Spain: Gamadiabet;

United Kingdom: Dimelor;

United States: Dymelor

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