Drug Approvals
(British Approved Name, US Adopted Name, rINN)
Pharmacopoeias. InJapan and US.
The United States Pharmacopeia 31, 2008 (Acetohexamide). A white, practically odourless, crystalline powder. Practically insoluble in water and in ether soluble 1 in 230 of alcohol and 1 in 210 of chloroform soluble in py-ridine and in dilute solutions of alkali hydroxides.
Profile
Acetohexamide is a sulfonylurea antidiabetic. Its duration of action is 12 hours or more. It has been given orally in the treatment of type 2 diabetes mellitus in a usual initial dose of 250 mg daily before breakfast. The daily dose may then be increased by 250 to 500 mg at intervals of 5 to 7 days, to a maintenance dose of up to 1.5 g daily increasing the dose above 1.5 g does not usually lead to further benefit. Doses in excess of 1 g daily may be taken in 2 divided doses, before the morning and evening meals.
Preparations
The United States Pharmacopeia 31, 2008: Acetohexamide Tablets.
Proprietary Preparations
Canada: Dimelor;
Hong Kong: Dimelor;
Italy: Dimelor;
South Africa: Dimelor;
Spain: Gamadiabet;
United Kingdom: Dimelor;
United States: Dymelor