Drug Approvals
(British Approved Name, rINN)
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
Pharmacopoeias. In China, and Europe.
European Pharmacopoeia, 6th ed. (Gliclazide). A white or almost white powder. Practically insoluble in water slightly soluble in alcohol sparingly soluble in acetone freely soluble in dichloromethane.
Adverse Effects, Treatment, and Precautions
As for sulfonylureas in general. The BNF suggests that gliclazide may be suitable for use in patients with renal impairment, but that careful monitoring of blood-glucose concentration is essential. UK licensed product information recommends that it should not be used in patients with severe renal impairment.
Interactions
As for sulfonylureas in general.
Pharmacokinetics
Gliclazide is readily absorbed from the gastrointestinal tract. It is extensively bound to plasma proteins. The half-life is about 10 to 12 hours. Gliclazide is extensively metabolised in the liver to metabolites that have no significant hypoglycaemic activity. Metabolites and a small amount of unchanged drug are excreted in the urine.
Uses and Administration
Gliclazide is a sulfonylurea antidiabetic. It is given orally in the treatment of type 2 diabetes mellitus and has a duration of action of 12 to 24 hours. Because its effects are less prolonged than those of chlorpropamide or glibenclamide it may be more suitable for elderly patients, who are prone to hypoglycaemia with longer-acting sulfonylureas. The usual initial dose is 40 to 80 mg daily, gradually increased, if necessary, up to 320 mg daily. Doses of more than 160 mg daily are given in 2 divided doses. A modified-release tablet is also available: the usual initial dose is 30 mg once daily, increased if necessary up to a maximum of 120 mg daily.
Preparations
British Pharmacopoeia 2008: Gliclazide Tablets.
Proprietary Preparations
Argentina: Aglucide Diamicron Unava
Australia: Diamicron Glyade Nidem Oziclide
Austria: Diamicron
Belgium: Diamicron Uni Diamicron
Brazil: Azukon Diamicron Glicaron
Canada: Diamicron
Chile: Dianormax
Czech Republic: Diabrezide Diaprel
Denmark: Diamicron
France: Diamicron
Germany: Diamicron
Greece: Diamicron
Hong Kong: CP-Gliz Diamicron Diamitex Dianorm Glimicron Glucozide Glupozide Glyzyl Licla Marclazide Nidem Qualizide Suclear Sun-Glizide
Hungary: Diaprel Gluctam
India: Diamicron Gliza Glizid Glycigon Glycinorm Glygard Lycazid Semi-Glycigon
Indonesia: Diamicron Fredam Glicab Glidabet Glucodex Glucored Glukolos Glycafor Linodiab Meltika Nufamicron Pedab Tiaglib Xepabet Zumadiac
Ireland: Diabrezide Diaclide Diamicron
Italy: Cronemet Diabrezide Diamicron Dramion Galtes Glucobloc
Malaysia: Diacron † Diamicron Dianid Glimicron Glucozide Glyade Medoclazide Melicron † Opglucon Reclide Sun-Glizide
Mexico: Diamicron
The Netherlands: Diamicron
New Zealand: Diamicron Glizon
Philippines: Clibite Glizid Diaclid Diamicron Dianorm Glubitor Gluconil Glucoprime
Poland: Diabezidum Diabrezide Diaprel Diazidan Glazide Glinormax Norsulin
Portugal: Diamicron
South Africa: Diaglucide Diamicron Glucomed Glycron Glygard Ziclin
Singapore: Diamicron Dianorm Glimicron Glizide Glucozide Medoclazide Melicron †
Spain: Diamicron Uni Diamicron
Switzerland: Diamicron
Thailand: Cadicon Diabeside Diaclaron † Diamaze † Diamexon Diamicron Dianid Glicron Glucocron Glucozide Glycon Medoclazide Serviclazide
Turkey: Betanorm Diamicron Glazid Glumikron Oramikron
United Arab Emirates: Glyzide
UK: Diaglyk Diamicron
Venezuela: Diamicron Glidan Reclide †
Multi-ingredient:
India: Exermet GZ Gliclamet Glizid-M Glycigon-M Glycinorm M Glygard M Glyroz.